Welcome to Cannabryl
Licensed to Manufacture Medicinal Cannabis Based Drugs
DEVELOPING - water-soluble nanoemulsion inhouse technology
We at Indogenix in 2020 financial year has planned to fully devout its energies into developing in house solution for water soluble nanoemulsions for full spectrum medical cannabis. This will involve processing of CBD oil already manufactured by Indogenix into a clear, water-soluble nanoemulsion.
We all know that oil and water don’t mix well. This reality makes things a bit tricky for CBD and other oil-soluble plant extracts because most products and supplements we use are not oil-based. What most people don’t know is that CBD, in its natural oil form, can only be effectively incorporated into the body through a narrow range of uses. The water-based biology of human bodies has difficulty accessing and absorbing oily molecules from ingested or topically applied hemp oil drops. Common oil-based delivery methods, like tinctures, are not meant to be swallowed, and for good reason. It all comes down something known as bioavailability, which indicates how much of any given substance is actually able to be absorbed by the body. There’s one bodily process in particular that’s responsible for preventing the effective absorbtion.
It would be like paying for a full tank of petrol and only getting 10–20%. That’s simply unacceptable.
First Pass Metabolism
First-pass metabolism (also referred to as the first-pass effect) is a physiological phenomenon in drug (plant extract) delivery science where the concentration of a compound is greatly reduced before it reaches systemic circulation. This concentration reduction means a decrease in bioavailability, and is a relatively common problem that affects a huge range of compounds including, morphine, curcumin (from turmeric), lidocaine, nitroglycerin, and many found in cannabis.
First-pass metabolism only affects the bioavailability of CBD when consumed orally, and there are some creative chemistry techniques used to get around it. Luckily, rubbing CBD into your skin, dropping some tincture under your tongue allows the CBD to directly enter systemic circulation. These delivery methods don’t go near any of the mechanisms associated with the first-pass effect, and bioavailability is not negatively affected.
Basically, you can think of medical cannabis extract in oil form is a big molecular piece. When this chunk of oil enters your stomach it’s too large to pass through your gut lining and enter systemic circulation without being broken down by enzymes and passed along the liver for processing. By converting the oil to a water-soluble powder, the oil-chunk is broken down into tiny, micro-sized pieces. These pieces of oil are very, very small, and are encapsulated within other non-toxic materials to ensure they remain stable in this new form. The end result of this process is an off-white, water-soluble, micro-encapsulated, full-spectrum, medicinal cannabis extract.
This conversion process completely overcomes the first-pass effect, and allows CBD oil (and other similar compounds) to be consumed orally without sacrificing bioavailability.
Converting CBD oil to a water-soluble powder greatly increases the ways in which it can be used. Not everyone wants to hold a tincture under their tongue or hit a vape pen in order to get their dose of CBD. Only by converting CBD oil into a water-soluble powder can we effectively incorporate CBD into these types of products. Water-soluble CBD powder opens up a world of possibilities. Not only does it allow us to effectively use capsules as a form of precise CBD delivery, but it also lets us use CBD in any drink or food product we can imagine.
DEVELOPING – Cultivation capabilities
We at indogenix is working with Indian government to gain medical cannabis cultivation license , this is really needed to bring a standardization into the medicines we produce , Since biomass generation capability only can lead to matching standard decided once . it is known that no true crops can be exactly safe if there environment differs.